1) " Prozac" -- As it applies to Prozac Wellbutrin Fluoxetine N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]-propan-1-amine hydrochloride CAS number 59333-67-4 ATC code ? Chemical formula C 17 H 18 F 3 3NO, HCl Molecular weight 345.8 Bioavailability ? Metabolism ? Elimination half-life ? Excretion ? Pregnancy category ? Legalstatus ? Routes of administration Oral Background Fluoxetine hydrochloride (brand names include Prozac®, Symbyax® [compounded with olanzapine ], Sarafem®, Fontex® [Sweden], Fluctine (Austria,Germany)) is an antidepressant drug used medically in the treatment of depression, obsessive-compulsive disorder, bulimia nervosa, premenstrual dysphoric disorder, and many other disorders. It is one of the selective serotonin reuptakeinhibitors, and is marketed in capsules containing 10, 20, or 40 mg of active ingredient or in tablets containing 10 mg.Dosages in the range of 20-60 mg per day are standard, with 80 mg considered a maximum. Eli Lilly's Prozca was approved by theFDA on December 27, 1987 and introducedin the US at the beginning of 1988.The drug became very popular, with millions around the world having taken the medication.Fluoxetine has a wide range of published interactions, notably with monoamine oxidase inhibitors. Common side-effects include anxiety, restlessness, trembling, weakness,skin rash, anorgasmia, itching, and adecrease in sexual drive. Fluoxetine is eliminated very slowly by the body. The half-life of fluoxetineafter a single dose is 2 days and after multiple dosing 4 days. The liver then metabolizes fluoxetine into norfluoxetine, adesmethyl metabolite, which is also a serotonin reuptake inhibitor; norfluoxetine has an even longer half-life, i.e. 8.6 and 9.3days for single and repeated dosage respectively. Fluoxetine is a potent ...
2) " Wellbutrin" -- As it applies to Prozac Wellbutrin Bupropion (±)-1-(3-chlorophenyl)-2-[(1,1-dimethylethyl)amino]-1-propanone Empiric formula C 13 H 18 Cl N O Molecular weight 239.74 Bioavailability? Metabolism Liver Elimination half life 20 hours Excretion Urine ATC code N07BA02 Pregnancy category B ( USA ) ? ( Aus ) Bupropion (amfebutamone) is an antidepressant of the amino ketone class, chemically unrelated to tricyclics or SSRIs. It is similar instructure to the stimulant cathinone, and to phenethylamines in general. Contents 1 History 2 Mode of action 3 Pharmacokinetics 4 Pills 5 Side effects 6 External links History Bupropion was first synthesized by Burroughs Research in 1966, and patented byBurroughs-Wellcome (later Glaxo-Wellcome) in 1974. It was approved by the FDA in 1985 and marketed under the name Wellbutrin as an antidepressant, but clinical trialsindicated that incidence of seizure was two to four times greater than otherantidepressants and the drug was quickly pulled from the market. Glaxo, realizing thatseizure risk was a function of dosage, then developed and marketed a sustained-release (SR) version of Welblutrin which, wheningested, releases bupropion hydrochloride at a constant, gradual rate into the body. Because of this altered mechanism ofdelivery, incidence of seizure with Wllbutrin -SR is comparable to, and in some cases, lower than that of otherantidepressants. In 1997, bupropion HCl was approved by the FDA for use as a smoking cessation aid.Because the name Wellnutrin was still associated with high seizure risk, the drug was subsequently marketed by Glaxo under thename Zyban to help people stop smoking tobacco by reducing theseverity of withdrawal symptoms. It can be used in combination with nicotine replacement therapies. Bupropion treatmentcourse lasts for seven to twelve weeks, the patient halting the...
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