1) " Depakote" -- As it applies to Depakote Valproic acid or 2-Propylpentanoic acid is C H 3 CH 2 CH 2 CH(CH 2 CH 2 CH 3 )C O OH. Sodium valproate (also known as valproate, or VPA) is a sodium salt of valproic acid. Divalproex Sodium - marketed by Abbott Laboratories as Depakote® in the USA and Canada and asEpilim® in the UK and Australia - is the semisodium salt of valproic acid, made by combining sodium valproate with valproic acid to form a chemical complex which containshalf the sodium of an equivalent dose of sodium valproate. Valproic acid, delivered in either of these forms, is a anticonvulsant and mood-stabilizing drug used primarily in the treatment of epilepsy and bipolar disorder ; but also used to treat migraine headaches and schizophrenia. In epileptics, valproic acid is used to control absence seizures, tonic-clonic seizures ( grand mal ), complex partial seizures, and the seizures associatedwith Lennox-Gastaut syndrome.Valproate is believed to affect the function of the neurotransmitter GABA (as a GABA transaminase inhibitor) inthe human brain. Side Effects Common side effects are dyspepsia and/or weight -gain. Less common are dizziness, drowsiness, hair -loss, headaches, nausea, sedation and tremors, Valproic acid can also rarely cause blood dyscrasia, impaired liver function, jaundice, thrombocytopenia, and prolonged coagulation times. In ~5% of pregnant users, valproic acid will cross the placenta and cause congenital anomalies. There have also been reports of cognitive dysfunction, Parkinsonian syndrome and even pseudoatrophicbrain changes in long-term treatment with valproic acid. External links The Lundbeck Institute Guide to Psychotropics - Valproic acid ( http: www.psychotropics.dk/usr_view_molecule.asp?ID=2372&backurl=Alphaindex%2Fview%5Falpha%2Easp%3FStartchar%3DD&...
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